Genetic inheritance is involved in the development of autism spectrum disorders (ASD). Genetic factors likely interact with environmental variables to result in the expression of autism. Neurobiological research indicates that autism is likely the result of genetically determined abnormalities in brain development. This abnormal brain development may start before the child is born. It has been difficult for genetics researchers to locate a specific chromosome(s) involved in autism but recent studies have identified several genetic mechanisms that each lead to autism.